A pharmacokinetic/pharmacodynamic mathematical model accurately describes the activity of voriconazole against Candida spp. in vitro

We developed a pharmacokinetic/pharmacodynamic (PK/PD) mathematical model that fits voriconazole time–kill data against Candida isolates in vitro and used the model to simulate the expected kill curves for typical intravenous and oral dosing regimens. A series of E(max) mathematical models were used...

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Bibliografiske detaljer
Main Authors: Li, Yanjun, Nguyen, M. Hong, Cheng, Shaoji, Schmidt, Stephan, Zhong, Li, Derendorf, Hartmut, Clancy, Cornelius J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2367122/
https://ncbi.nlm.nih.gov/pubmed/18215509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2007.11.015
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