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Tyrosine kinase inhibitors and immunosuppressants perturb the myo-inositol but not the betaine cotransporter in isotonic and hypertonic MDCK cells

BACKGROUND: The sodium/myo-inositol cotransporter (SMIT) and the betaine cotransporter (BGT1) are essential for the accumulation of myo-inositol and betaine, and hence cell survival in a hypertonic environment. The underlying molecular mechanism involves an increase in transcription of the SMIT and...

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Bibliografske podrobnosti
Main Authors: Atta, Mohamed G., Dahl, Stephen C., Kwon, H. Moo, Handler, Joseph S.
Format: Artigo
Jezik:Inglês
Izdano: 1999
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366806/
https://ncbi.nlm.nih.gov/pubmed/10027932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1523-1755.1999.055003956.x
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