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Regulation of Sindbis virus RNA replication: uncleaved P123 and nsP4 function in minus-strand RNA synthesis, whereas cleaved products from P123 are required for efficient plus-strand RNA synthesis.

Nonstructural proteins of Sindbis virus, nsP1, nsP2, nsP3, and nsP4, as well as intermediate polyproteins, are produced from two precursor polyproteins, P123 and P1234, by a proteolytic enzyme encoded in the C-terminal half of nsP2. We studied the requirements for and the functions of the intermedia...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Shirako, Y, Strauss, J H
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 1994
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236650/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8107248/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.3.1874-1885.1994
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