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Murine β-defensin 2 promotes TLR-4/MyD88-mediated and NF-κB-dependent atypical death of APCs via activation of TNFR2

Mammalian antimicrobial peptides, including β-defensins, represent an ancient arm of innate immunity designed to directly neutralize invading microbes. Previously, we demonstrated that murine β-defensin 2 (mDF2β) also acted as an endogenous ligand for TLR-4-activating maturation of dendritic cells (...

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Detalhes bibliográficos
Main Authors: Biragyn, Arya, Coscia, Marta, Nagashima, Kunio, Sanford, Michael, Young, Howard A., Olkhanud, Purevdorj
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365917/
https://ncbi.nlm.nih.gov/pubmed/18192488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1007700
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