Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-α release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors

We investigated the effects of specific inhibitors of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) on the inhibitory activity of phosphodiesterase (PDE) type 4 inhibitors and of the cell permeable analogue of cAMP, db-cAMP on LPS-induced TNF-α release from human mononu...

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Détails bibliographiques
Auteurs principaux: Hichami, A., Boichot, E., Germain, N., Berdyshev, E., Coqueret, O., Lagente, V.
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365824/
https://ncbi.nlm.nih.gov/pubmed/18475747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/S0962935196000580
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