Severe Depletion of Mucosal CD4(+) T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys

HIV-infected humans and SIV-infected rhesus macaques experience a rapid and dramatic loss of mucosal CD4(+) T cells that is considered to be a key determinant of AIDS pathogenesis. In this study, we show that nonpathogenic SIV infection of sooty mangabeys (SMs), a natural host species for SIV, is al...

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Main Authors: Gordon, Shari N., Klatt, Nichole R., Bosinger, Steven E., Brenchley, Jason M., Milush, Jeffrey M., Engram, Jessica C., Dunham, Richard M., Paiardini, Mirko, Klucking, Sara, Danesh, Ali, Strobert, Elizabeth A., Apetrei, Cristian, Pandrea, Ivona V., Kelvin, David, Douek, Daniel C., Staprans, Silvija I., Sodora, Donald L., Silvestri, Guido
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365740/
https://ncbi.nlm.nih.gov/pubmed/17709517
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