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IL-4 induces cAMP and cGMP in human monocytic cells

Human monocytes, preincubated with IFN-γ respond to IL-4 by a cGMP increase through activation of an inducible NO synthase. Here, IL-4 was found to induce an accumulation of cGMP (1 – 3 min) and cAMP (20 – 25 min) in unstimulated monocytes. This was impaired with NOS inhibitors, but also with EGTA a...

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Detalhes bibliográficos
Main Authors: Dugas, B., Paul-Eugene, N., Yamaoka, K., Amirand, C., Damais, C., Kolb, J. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 1995
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365639/
https://ncbi.nlm.nih.gov/pubmed/18475655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/S0962935195000482
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