Cytotoxic Activity of Silyl- and Germyl-Substituted 4,4-Dioxo-3a,6a-Dihydrothieno[2,3−d]isoxazolines-2

The [2+3] dipolar cycloaddition of nitrile oxides to the double C = C bonds of thiophene-1, 1-dioxides leads to formation of the fused isoxazolines-2 (1, 2). Tumor growth inhibition of these compounds strongly depends on the nature of group IV A element increasing from slightly active tert-butyl der...

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Detalhes bibliográficos
Principais autores: Lukevics, E., Arsenyan, P., Shestakova, I., Zharkova, O., Kanepe, I., Mezapuke, R., Pudova, O.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2365205/
https://ncbi.nlm.nih.gov/pubmed/18475927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/MBD.2000.63
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