Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site.

The swine-specific coronavirus transmissible gastroenteritis virus (TGEV) uses pig aminopeptidase-N (pAPN) as a cellular receptor. We showed that the human aminopeptidase-N (hAPN) cannot substitute for pAPN in this respect, although the two enzymes have 80% amino acid sequence identity. In order to...

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Autors principals: Delmas, B, Gelfi, J, Kut, E, Sjöström, H, Noren, O, Laude, H
Format: Artigo
Idioma:Inglês
Publicat: 1994
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC236465/
https://ncbi.nlm.nih.gov/pubmed/7913510
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