Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site.

The swine-specific coronavirus transmissible gastroenteritis virus (TGEV) uses pig aminopeptidase-N (pAPN) as a cellular receptor. We showed that the human aminopeptidase-N (hAPN) cannot substitute for pAPN in this respect, although the two enzymes have 80% amino acid sequence identity. In order to...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Delmas, B, Gelfi, J, Kut, E, Sjöström, H, Noren, O, Laude, H
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236465/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7913510/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.8.5216-5224.1994
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