Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue

ZD2767P is a phenol mustard glutamate prodrug which is currently being developed for Antibody Directed Enzyme Prodrug Therapy (ADEPT). In ZD2767 ADEPT an active bi-functional alkylating drug, ZD2767D (4-[N,N-bis(2-iodoethyl)amino]phenol), is generated following cleavage of ZD2767P by the bacterial e...

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Main Authors: Monks, N R, Blakey, D C, Curtin, N J, East, S J, Heuze, A, Newell, D R
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2001
主題:
Regular Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364118/
https://ncbi.nlm.nih.gov/pubmed/11531265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2001.1947
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