N -butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours

Abnormalities in glycosphingolipid (GSL) biosynthesis have been implicated in the oncogenesis and malignancy of brain tumours. GSLs comprise the gangliosides and the neutral GSLs and are major components of the cell surface glycocalyx. N -butyldeoxynojirimycin (N B-DNJ) is an imino sugar that inhibi...

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Bibliografiske detaljer
Main Authors: Ranes, M K, El-Abbadi, M, Manfredi, M G, Mukherjee, P, Platt, F M, Seyfried, T N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363859/
https://ncbi.nlm.nih.gov/pubmed/11308262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1713
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