Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer

Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0....

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Autori principali: Leung, W K, To, K-F, Ng, Y-P, Lee, T-L, Lau, J Y W, Chan, F K L, Ng, E K W, Chung, S C S, Sung, J J Y
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2001
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363738/
https://ncbi.nlm.nih.gov/pubmed/11161397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1607
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