The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation.

The 44-amino-acid E5 protein of bovine papillomavirus type 1 is a highly hydrophobic protein which appears to transform cells through the activation of growth factor receptors. To investigate the specificity of E5-growth factor receptor interactions required for mitogenic signaling, we utilized a no...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Goldstein, D J, Li, W, Wang, L M, Heidaran, M A, Aaronson, S, Shinn, R, Schlegel, R, Pierce, J H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236368/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8207816/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.7.4432-4441.1994
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