Screening for BRCA2 mutations in 81 Dutch breast–ovarian cancer families

We have analysed 81 families with a history of breast and/or ovarian cancer for the presence of germline mutations in BRCA2 with a number of different mutation screening techniques. The protein truncation test (PTT) for exons 10 and 11 detected four different frame-shifting mutations in six of these...

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Hlavní autoři: Peelen, T, Vliet, M van, Bosch, A, Bignell, G, Vasen, H F A, Klijn, J G M, Meijers-Heijboer, H, Stratton, M, Ommen, G-J B van, Cornelisse, C J, Devilee, P
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2000
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363204/
https://ncbi.nlm.nih.gov/pubmed/10638982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.1999.0892
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