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Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α(1)-acid glycoprotein binding

Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein α(1)-acid glycoprotein (...

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מידע ביבליוגרפי
Main Authors: Curtin, N J, Bowman, K J, Turner, R N, Huang, B, Loughlin, P J, Calvert, A H, Golding, B T, Griffin, R J, Newell, D R
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 1999
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363125/
https://ncbi.nlm.nih.gov/pubmed/10468290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690591
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