Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α(1)-acid glycoprotein binding

Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein α(1)-acid glycoprotein (...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Curtin, N J, Bowman, K J, Turner, R N, Huang, B, Loughlin, P J, Calvert, A H, Golding, B T, Griffin, R J, Newell, D R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 1999
Aiheet:
Regular Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363125/
https://ncbi.nlm.nih.gov/pubmed/10468290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690591
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