Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced α(1)-acid glycoprotein binding

Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein α(1)-acid glycoprotein (...

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Hlavní autoři: Curtin, N J, Bowman, K J, Turner, R N, Huang, B, Loughlin, P J, Calvert, A H, Golding, B T, Griffin, R J, Newell, D R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1999
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363125/
https://ncbi.nlm.nih.gov/pubmed/10468290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690591
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