Tumour cells engineered to secrete interleukin-15 augment anti-tumour immune responses in vivo

We examined the effect of interleukin-15 (IL-15) gene transfer into tumour cells on the host's anti-tumour response. In BALB/c mice IL-15 producing Meth-A cells (Meth-A/IL-15) underwent complete rejection, in a response characterized by massive infiltration of CD4(+) T-cells and neutrophils. In...

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Hlavní autoři: Hazama, S, Noma, T, Wang, F, Iizuka, N, Ogura, Y, Yoshimura, K, Inoguchi, E, Hakozaki, M, Hirose, K, Suzuki, T, Oka, M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1999
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363078/
https://ncbi.nlm.nih.gov/pubmed/10424745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690538
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