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PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma

Increased mortality of patients with oral cancer largely reflects the local and regional spread of the disease. The invasiveness of these tumours requires hydrolases which are regulated through AP-1-dependent transcriptional mechanisms. Since the amount/activity of transcription factors bound to the...

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Detalhes bibliográficos
Main Authors: Simon, C, Hicks, M J, Nemechek, A J, Mehta, R, Jr, B W O'Malley, Goepfert, H, Flaitz, C M, Boyd, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363077/
https://ncbi.nlm.nih.gov/pubmed/10424744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690537
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