Randomized trial to compare the efficacy and toxicity of cyclophosphamide, methotrexate and 5-fluorouracil (CMF) with methotrexate mitoxantrone (MM) in advanced carcinoma of the breast

One hundred and sixteen patients with locally advanced or metastatic breast cancer were randomized to receive CMF (cyclophosphamide 600 mg m(−2) day 1 and 8 i.v., 5-fluorouracil 600 mg m(−2) day 1 and 8 i.v.,, methotrexate 40 mg m(−2) day 1 and 8 i.v., monthly for 6 cycles) or MM (methotrexate 30 mg...

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Detalhes bibliográficos
Main Authors: Harper-Wynne, C, English, J, Meyer, L, Bower, M, Archer, C, Sinnett, H D, Lowdell, C, Coombes, R C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362871/
https://ncbi.nlm.nih.gov/pubmed/10496359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6990694
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