Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate

Immunization of macaques with multivalent DNA encoding gp120 genes from HIV-1 subtypes A, B, C and E and a gag gene followed by boosting with homologous gp120 proteins elicited strong anti-gp120 antibodies capable of neutralizing homologous and to a lesser degree heterologous HIV-1 isolates. Both En...

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Hauptverfasser: Pal, Ranajit, Wang, Shixia, Kalyanaraman, V.S., Nair, B.C., Whitney, Stephen, Keen, Timothy, Hocker, Lindsey, Hudacik, Lauren, Rose, Nicolas, Cristillo, Anthony, Mboudjeka, Innocent, Shen, Siyuan, Wu-Chou, Te-Hui, Montefiori, David, Mascola, John, Lu, Shan, Markham, Phillip
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362402/
https://ncbi.nlm.nih.gov/pubmed/16128917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0684.2005.00120.x
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