Thalidomide increases both intra-tumoural tumour necrosis factor-α production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid

5,6-Dimethylxanthenone-4-acetic acid (DMXAA), synthesized in this laboratory and currently in phase I clinical trial, is a low molecular weight inducer of tumour necrosis factor-α (TNF-α). Administration of DMXAA to mice with established transplantable tumours elicits rapid vascular collapse selecti...

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Detalhes bibliográficos
Main Authors: Cao, Z, Joseph, W R, Browne, W L, Mountjoy, K G, Palmer, B D, Baguley, B C, Ching, L-M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362281/
https://ncbi.nlm.nih.gov/pubmed/10360649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690415
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