A randomised factorial trial of sequential doxorubicin and CMF vs CMF and chemotherapy alone vs chemotherapy followed by goserelin plus tamoxifen as adjuvant treatment of node-positive breast cancer

The sequential doxorubicin → CMF (CMF=cyclophosphamide, methotrexate, fluorouracil) regimen has never been compared to CMF in a randomised trial. The role of adding goserelin and tamoxifen after chemotherapy is unclear. In all, 466 premenopausal node-positive patients were randomised to: (a) CMF × 6...

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Autori principali: De Placido, S, De Laurentiis, M, De Lena, M, Lorusso, V, Paradiso, A, D'Aprile, M, Pistillucci, G, Farris, A, Sarobba, M G, Palazzo, S, Manzione, L, Adamo, V, Palmeri, S, Ferraù, F, Lauria, R, Pagliarulo, C, Petrella, G, Limite, G, Costanzo, R, Bianco, A R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2005
Soggetti:
Clinical Study
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362097/
https://ncbi.nlm.nih.gov/pubmed/15668708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602355
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