Carboxypeptidase G(2) rescue in patients with methotrexate intoxication and renal failure

The methotrexate (MTX) rescue agent carboxypeptidase G(2) (CPDG(2)) rapidly hydrolyses MTX to the inactive metabolite DAMPA (4-[[2,4-diamino-6-(pteridinyl)methyl]-methylamino]-benzoic acid) and glutamate in patients with MTX-induced renal failure and delayed MTX excretion. DAMPA is thought to be an...

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Bibliografiska uppgifter
Huvudupphovsmän: Buchen, S, Ngampolo, D, Melton, R G, Hasan, C, Zoubek, A, Henze, G, Bode, U, Fleischhack, G
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2005
Ämnen:
Clinical Study
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362096/
https://ncbi.nlm.nih.gov/pubmed/15668713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602337
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