17β-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer

The 17β-hydroxysteroid dehydrogenase (17HSD) enzymes are involved in the local regulation of sex steroids. The 17HSD type 1 enzyme catalyses the interconversion of the weak oestrone (E1) to the more potent oestradiol (E2), whereas 17HSD type 2 catalyses the oxidation of E2 to E1. The aim of this stu...

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Bibliografiske detaljer
Main Authors: Gunnarsson, C, Hellqvist, E, Stål, O
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2005
Fag:
Molecular Diagnostics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362090/
https://ncbi.nlm.nih.gov/pubmed/15685233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602375
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