Benzo[b]thiophenesulphonamide 1,1-dioxide derivatives inhibit tNOX activity in a redox state-dependent manner

Benzo[b]thiophenesulphonamide 1,1-dioxide (BTS) derivatives are strong cytotoxic agents that induce reactive oxygen species (ROS) overproduction and apoptosis in tumour cells. Although the precise origin of BTS-induced ROS is not known, a clear correlation between their cytotoxic effect and ability...

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Bibliografiska uppgifter
Huvudupphovsmän: Encío, I, Morré, D J, Villar, R, Gil, M J, Martínez-Merino, V
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2005
Ämnen:
Translational Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361890/
https://ncbi.nlm.nih.gov/pubmed/15685230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602383
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