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Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence
Activation of the endothelin A receptor (ET(A)) by endothelin-1 (ET-1) mediates events that regulate mitogenesis, apoptosis, angiogenesis and metastasis in tumours. Specific blockade of ET(A) may have anticancer effects, while retaining beneficial endothelin B receptor (ET(B))-mediated effects such...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2361809/ https://ncbi.nlm.nih.gov/pubmed/15956965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602676 |
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