Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence

Activation of the endothelin A receptor (ET(A)) by endothelin-1 (ET-1) mediates events that regulate mitogenesis, apoptosis, angiogenesis and metastasis in tumours. Specific blockade of ET(A) may have anticancer effects, while retaining beneficial endothelin B receptor (ET(B))-mediated effects such...

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Detaylı Bibliyografya
Asıl Yazarlar: Morris, C D, Rose, A, Curwen, J, Hughes, A M, Wilson, D J, Webb, D J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2005
Konular:
Clinical Study
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361809/
https://ncbi.nlm.nih.gov/pubmed/15956965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602676
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