A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer

Inhibition of epidermal growth factor receptor (EGFR) signalling contributes to the therapy of colorectal cancer. Gefitinib, an oral EGFR tyrosine kinase inhibitor, shows supra-additive growth inhibition with irinotecan and fluoropyrimidines in xenograft models. We designed a study to determine the...

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Detalhes bibliográficos
Main Authors: Veronese, M L, Sun, W, Giantonio, B, Berlin, J, Shults, J, Davis, L, Haller, D G, O'Dwyer, P J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361767/
https://ncbi.nlm.nih.gov/pubmed/15870719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602569
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