Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid

Oxyphil or Hürthle cell tumours of the thyroid are characterised by their consistent excessive number of mitochondria. A recently discovered gene, GRIM-19 has been found to fulfil two roles within the cell: as a member of the interferon-β and retinoic acid-induced pathway of cell death, and as part...

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Detalhes bibliográficos
Main Authors: Máximo, V, Botelho, T, Capela, J, Soares, P, Lima, J, Taveira, A, Amaro, T, Barbosa, A P, Preto, A, Harach, H R, Williams, D, Sobrinho-Simões, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361763/
https://ncbi.nlm.nih.gov/pubmed/15841082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602547
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