Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2α may signal skeletal muscle atrophy in weight-losing cancer patients

Previous studies suggest that the activation (autophosphorylation) of dsRNA-dependent protein kinase (PKR) can stimulate protein degradation, and depress protein synthesis in skeletal muscle through phosphorylation of the translation initiation factor 2 (eIF2) on the α-subunit. To understand whether...

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Detalhes bibliográficos
Main Authors: Eley, H L, Skipworth, R J E, Deans, D A C, Fearon, K C H, Tisdale, M J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361431/
https://ncbi.nlm.nih.gov/pubmed/18087277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604150
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