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ARF-BP1 as a potential therapeutic target

In this review, we discuss the recent identification of ARF-BP1 (also known as Mule, UREB1, E3(histone), LASU1, and HectH9). ARF-BP1, a HECT domain-containing E3 ubiquitin ligase, interacts with ARF and p53. Its ubiquitin ligase activity is inhibited by ARF. Inactivation of ARF-BP1 stabilised p53 an...

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Detalhes bibliográficos
Main Authors: Chen, D, Brooks, C L, Gu, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361317/
https://ncbi.nlm.nih.gov/pubmed/16641901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603119
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