E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines

Using genome-wide expression profiling of a panel of 27 human mammary cell lines with different mechanisms of E-cadherin inactivation, we evaluated the relationship between E-cadherin status and gene expression levels. Expression profiles of cell lines with E-cadherin (CDH1) promoter methylation wer...

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Dettagli Bibliografici
Autori principali: Lombaerts, M, van Wezel, T, Philippo, K, Dierssen, J W F, Zimmerman, R M E, Oosting, J, van Eijk, R, Eilers, P H, van de Water, B, Cornelisse, C J, Cleton-Jansen, A-M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2006
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361216/
https://ncbi.nlm.nih.gov/pubmed/16495925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602996
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