Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma

A two-stage Simon design was used to evaluate the response rate of OSI-7904L, a liposome encapsulated thymidylate synthase inhibitor, in advanced gastric and/or gastroesophageal adenocarcinoma (A-G/GEJA), administered intravenously at 12 mg m(−2) over 30 min every 21 days. Fifty patients were treate...

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Detalhes bibliográficos
Main Authors: Falk, S, Anthoney, A, Eatock, M, Van Cutsem, E, Chick, J, Glen, H, Valle, J W, Drolet, D W, Albert, D, Ferry, D, Ajani, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360664/
https://ncbi.nlm.nih.gov/pubmed/16880795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603267
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