Temozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: phase II study from gruppo italiano cooperativo di neuro-oncologia (GICNO)

The efficacy of temozolomide strongly depends on O(6)-alkylguanine DNA-alkyl transferase (AGAT), which repairs DNA damage caused by the drug itself. Low-dose protracted temozolomide administration can decrease AGAT activity. The main end point of the present study was therefore to test progression-f...

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Detalhes bibliográficos
Main Authors: Brandes, A A, Tosoni, A, Cavallo, G, Bertorelle, R, Gioia, V, Franceschi, E, Biscuola, M, Blatt, V, Crinò, L, Ermani, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360560/
https://ncbi.nlm.nih.gov/pubmed/17024124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603376
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