Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo

The unique properties of the tumour microenvironment can be exploited by using recombinant anaerobic clostridial spores as highly selective gene delivery vectors. Although several recombinant Clostridium species have been generated during the past decade, their efficacy has been limited. Our goal wa...

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Detalhes bibliográficos
Main Authors: Theys, J, Pennington, O, Dubois, L, Anlezark, G, Vaughan, T, Mengesha, A, Landuyt, W, Anné, J, Burke, P J, Dûrre, P, Wouters, B G, Minton, N P, Lambin, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360559/
https://ncbi.nlm.nih.gov/pubmed/17024128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603367
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