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Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules

The purpose of this study was to investigate the utility of plasma pharmacokinetic and pharmacodynamic measures including plasma deoxynucleosides, homocysteine and methylmalonic acid concentrations in understanding the time course and extent of the inhibition of thymidylate synthase (TS) by pemetrex...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, K M, Rivory, L P, Clarke, S J
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360430/
https://ncbi.nlm.nih.gov/pubmed/17912246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603995
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