Development of IFN-γ resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells

The resistance to interferons (IFNs) limits their anticancer therapeutic efficacy. Here we studied the evolution of an IFN-resistant state in vitro using melanoma cell lines. We found that the cells became less sensitive to antiproliferative effect of IFN-γ after prolonged cultivation enabling us to...

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Detalhes bibliográficos
Main Authors: Fojtova, M, Boudny, V, Kovarik, A, Lauerova, L, Adamkova, L, Souckova, K, Jarkovsky, J, Kovarik, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360293/
https://ncbi.nlm.nih.gov/pubmed/17579625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603849
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