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Targeting BRAF in thyroid cancer

Activating mutations in the gene encoding BRAF are the most commonly identified oncogenic abnormalities in papillary thyroid cancer. In vitro and in vivo models have demonstrated that overexpression of activated BRAF induces malignant transformation and aggressive tumour behaviour. BRAF and other RA...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Espinosa, A V, Porchia, L, Ringel, M D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360215/
https://ncbi.nlm.nih.gov/pubmed/17179987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603520
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