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The p53 codon 72 proline allele is endowed with enhanced cell-death inducing potential in cancer cells exposed to hypoxia

The preferential retention of the arginine allele at the p53 codon 72 locus is commonly observed in tumours from arginine/proline heterozygotes. Considering that cancer cells are harboured in a hypoxic environment in vivo, we here tested the hypothesis that the p53 codon 72 proline allele confers a...

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Main Authors: Sansone, P, Storci, G, Pandolfi, S, Montanaro, L, Chieco, P, Bonafé, M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360160/
https://ncbi.nlm.nih.gov/pubmed/17406354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603723
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