Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells

Oxaliplatin (OHP) is an anticancer agent that acts by formation of Platinum-DNA (Pt-DNA) adducts resulting in DNA-strand breaks and is used for the treatment of colorectal cancer. The pyrimidine analog trifluorothymidine (TFT) forms together with a thymidine phosphorylase inhibitor (TPI) the antican...

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Main Authors: Temmink, O H, Hoebe, E K, van der Born, K, Ackland, S P, Fukushima, M, Peters, G J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360012/
https://ncbi.nlm.nih.gov/pubmed/17242697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603549
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