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A phase I study of bendamustine hydrochloride administered day 1+2 every 3 weeks in patients with solid tumours

The aim of the study was to determine the maximum tolerated dose (MTD), the dose limiting toxicity (DLT), and the pharmacokinetic profile (P(k)) of bendamustine (BM) on a day 1 and 2 every 3 weeks schedule and to recommend a safe phase II dose for further testing. Patients with solid tumours beyond...

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Hlavní autoři: Rasschaert, M, Schrijvers, D, Van den Brande, J, Dyck, J, Bosmans, J, Merkle, K, Vermorken, J B
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359912/
https://ncbi.nlm.nih.gov/pubmed/17486132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603776
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