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A dry ligand-binding cavity in a solvated protein
Ligands usually bind to proteins by displacing water from the binding site. The affinity and kinetics of binding therefore depend on the hydration characteristics of the site. Here, we show that the extreme case of a completely dehydrated free binding site is realized for the large nonpolar binding...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2359778/ https://ncbi.nlm.nih.gov/pubmed/18427121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709844105 |
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