Llwytho...

A dry ligand-binding cavity in a solvated protein

Ligands usually bind to proteins by displacing water from the binding site. The affinity and kinetics of binding therefore depend on the hydration characteristics of the site. Here, we show that the extreme case of a completely dehydrated free binding site is realized for the large nonpolar binding...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Qvist, Johan, Davidovic, Monika, Hamelberg, Donald, Halle, Bertil
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359778/
https://ncbi.nlm.nih.gov/pubmed/18427121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709844105
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