Bromodomain 4 activation predicts breast cancer survival

Previous work identified the Rap1 GTPase-activating protein Sipa1 as a germ-line-encoded metastasis modifier. The bromodomain protein Brd4 physically interacts with and modulates the enzymatic activity of Sipa1. In vitro analysis of a highly metastatic mouse mammary tumor cell line ectopically expre...

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Detalles Bibliográficos
Main Authors: Crawford, Nigel P. S., Alsarraj, Jude, Lukes, Luanne, Walker, Renard C., Officewala, Jennifer S., Yang, Howard H., Lee, Maxwell P., Ozato, Keiko, Hunter, Kent W.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359777/
https://ncbi.nlm.nih.gov/pubmed/18427120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710331105
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