Targeted killing of colorectal cancer cell lines by a humanised IgG1 monoclonal antibody that binds to membrane-bound carcinoembryonic antigen

The distribution of carcinoembryonic antigen (CEA) in colorectal cancer (CRC) differs from that in normal colorectal tissue, being found on all borders of the cell membrane and hence enabling access to intravenous antibody, making CEA a good target for antibody-based therapy. The distinctive anti-CE...

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Detalhes bibliográficos
Main Authors: Conaghan, P J, Ashraf, S Q, Tytherleigh, M G, Wilding, J L, Tchilian, E, Bicknell, D, Mortensen, N JMcC, Bodmer, W F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359646/
https://ncbi.nlm.nih.gov/pubmed/18349843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604289
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