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Vaccination and the dynamics of immune evasion

Vaccines exert strong selective pressures on pathogens, favouring the spread of antigenic variants. We propose a simple mathematical model to investigate the dynamics of a novel pathogenic strain that emerges in a population where a previous strain is maintained at low endemic level by a vaccine. We...

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Detalhes bibliográficos
Main Authors: Restif, Olivier, Grenfell, Bryan T
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2358969/
https://ncbi.nlm.nih.gov/pubmed/17210532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2006.0167
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