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Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells

Human serum albumin (HSA) derivatized with cis-aconitic anhydride was covalently coupled to liposomes with a size of approximately 100 nm [polyaconitylated HSA (Aco-HSA) liposomes]. Within 30 min after injection into a rat, Aco-HSA liposomes were completely cleared from the blood and almost exclusiv...

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Detalhes bibliográficos
Main Authors: Kamps, Jan A. A. M., Morselt, Henriëtte W. M., Swart, Pieter J., Meijer, Dick K. F., Scherphof, Gerrit L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC23586/
https://ncbi.nlm.nih.gov/pubmed/9326670
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