Interferon β transduction of peripheral blood lymphocytes from HIV-infected donors increases Th1-type cytokine production and improves the proliferative response to recall antigens

We are developing a gene therapy method of HIV infection based on the constitutive low production of interferon (IFN) β. Peripheral blood lymphocytes (PBL) from HIV-infected patients at different clinical stages of infection were efficiently transduced with the HMB-H(b)HuIFNβ retroviral vector. The...

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Autores principales: Vieillard, Vincent, Cremer, Isabelle, Lauret, Evelyne, Rozenbaum, Willy, Debré, Patrice, Autran, Brigitte, De Maeyer, Edward
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC23550/
https://ncbi.nlm.nih.gov/pubmed/9326655
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