Inherited human cPLA(2α) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

Cytosolic phospholipase A(2α )(cPLA(2α)) hydrolyzes arachidonic acid from cellular membrane phospholipids, thereby providing enzymatic substrates for the synthesis of eicosanoids, such as prostaglandins and leukotrienes. Considerable understanding of cPLA(2α )function has been derived from investiga...

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Detalhes bibliográficos
Main Authors: Adler, David H., Cogan, Joy D., Phillips, John A., Schnetz-Boutaud, Nathalie, Milne, Ginger L., Iverson, Tina, Stein, Jeffrey A., Brenner, David A., Morrow, Jason D., Boutaud, Olivier, Oates, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2350426/
https://ncbi.nlm.nih.gov/pubmed/18451993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30473
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