Inherited human cPLA(2α) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

Cytosolic phospholipase A(2α )(cPLA(2α)) hydrolyzes arachidonic acid from cellular membrane phospholipids, thereby providing enzymatic substrates for the synthesis of eicosanoids, such as prostaglandins and leukotrienes. Considerable understanding of cPLA(2α )function has been derived from investiga...

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Autores principales: Adler, David H., Cogan, Joy D., Phillips, John A., Schnetz-Boutaud, Nathalie, Milne, Ginger L., Iverson, Tina, Stein, Jeffrey A., Brenner, David A., Morrow, Jason D., Boutaud, Olivier, Oates, John A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2350426/
https://ncbi.nlm.nih.gov/pubmed/18451993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30473
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