C. elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity

Insulin regulates development, metabolism, and lifespan via a conserved PI3K/Akt pathway that promotes cytoplasmic sequestration of FoxO transcription factors. The regulation of nuclear FoxO is poorly understood. In the nematode Caenorhabditis elegans, insulin-like signaling functions in larvae to i...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Yanmei, Xu, Jinling, Puscau, Cristina, Kim, Yongsoon, Wang, Xi, Alam, Hena, Hu, Patrick J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2350227/
https://ncbi.nlm.nih.gov/pubmed/18241854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.12.032
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